Transform, transforming, and transformative are common terms for describing museum spaces, the creation of objects on display, and experiences for visitors. But is there evidence that museums profoundly change visitors through their objects, collections, exhibitions, public programs, and websites? The nature of transformational museum experiences and potential ‘triggers for transformation’ are the focus of this article. Two case studies describe ways in which visitors articulate change they have experienced. Included are projects about teachers and artists during an intense two-week summer institute in an interdisciplinary museum and about visitors to a traveling exhibition highlighting the role Canada plays in international development. Individuals’ comments and questions indicated that experiences with authentic objects and the unexpected, highly emotional responses, new cultural and attitudinal understandings, as well as motivation to become more proactive in the way they live their lives, may have been triggers for transformational experiences.